New Type 2 Diabetes Drug Helps Lower Blood Sugar: Study - MedicineNet How To Get Low Blood Sugar - Managing Blood Sugar: Your Guide to a Healthy Lifestyle

New Type 2 Diabetes Drug Helps Lower Blood Sugar: Study - MedicineNet

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By Serena Gordon

HealthDay Reporter

MONDAY, March 19 (HealthDay News) -- A modern sort of medication for type 2 diabetes helps to under blood sugar levels when used inside concert with insulin including more diabetes drugs, modern research suggests.

The medicine is called dapagliflozin, including average blood sugar levels were under inside those charming the medication compared to those charming a placebo; both groups inside the trial too took insulin including more diabetes medications. Daily insulin doses went to the other end of for those supported by the drug, including physique mass dropped slightly.

"This study looked at the effects of dapagliflozin care inside persons with sort 2 diabetes with high blood sugars despite insulin treatment, including start it was successful at reducing blood sugar, physique mass including blood pressure," said study author Dr. John Wilding, skull of the department of obesity including endocrinology at the University Hospital Aintree inside Liverpool, England.

"Possible disadvantages include a a bit higher risk of urine infections including genital fungal infections, while the majority of these responded skilfully to level treatment," he added.

Results of the study are published inside the March 20 topic of the Annals of Internal Medicine. The study was funded through AstraZeneca including Bristol-Meyers Squibb, two pharmaceutical companies who are collaborating inside the increase of dapagliflozin.

Type 2 diabetes affects the way your physique metabolizes sugar. In sort 2 diabetes, the physique either doesn't use the hormone insulin really or it doesn't make sufficient insulin, according to the U.S. National Library of Medicine. Insulin allows the body's cells to change sugar from food into fuel. If it isn't used skilfully or there's not sufficient insulin, blood sugar levels drive rise. High blood sugar levels can origin a number of grave health consequences, including damage to the eyes, kidneys including blood vessels.

In some cases, sort 2 diabetes can be controlled with lifestyle changes, such while losing mass including exercising regularly. However, the majority persons need medications to power their blood sugar levels, including various persons need a combination of medications to under their blood sugar.

Dapagliflozin is from a modern class of sort 2 diabetes medications that do business through blocking the ability of the kidneys to carry sugar. This causes the kidneys to free sugar while waste inside the urine.

Numerous clinical trials own start dapagliflozin to be successful at lowering blood sugar levels. Despite this beneficial effect, the U.S. Food including Drug Administration not long ago decided not to approve dapagliflozin till extra details is accessible regarding its feasible long-term border effects. The the majority significant anxiety cited through the FDA was a potential increase inside the rates of bladder including breast cancer inside persons charming the drug.

Although the course trial wasn't long sufficient to see for longer-term outcomes, such while cancer, Wilding said that the minor increase inside bladder including feelings cancer was inclined a chance finding. But, he said, because there is concern, it's important to keep on surveillance for these cancers inside future trials.

The course study was designed to perceive how the medication would do business inside combination with insulin including more sort 2 diabetes medications.

The researchers enrolled just over 800 persons with sort 2 diabetes who were already charming insulin to power their blood sugar levels. In addition, the study volunteers could be charming up to two extra blood sugar-lowering medications.

Study participants were randomly assigned to single of four care groups. They received either a placebo, or single of three doses of dapagliflozin (2.5, 5 or 10 milligrams) daily.

After 24 weeks of treatment, persons inside the dapagliflozin crowd lowered their average hemoglobin A1C level among 0.79 percent to 0.96 percent compared with a 0.39 percent reduction inside those supported by placebo. Hemoglobin A1C is regarding a three-month average blood sugar level. People with diabetes are advised to keep their levels below 7 percent.

Insulin use too dropped for persons charming the medication, suggesting extra successful blood sugar control. And, physique mass decreased among 2 pounds including 3.5 pounds for those charming the medication. Weight increased through almost 1 pound for those supported by placebo, according to the study.

In addition, the researchers start that both systolic including diastolic blood force levels went to the other end of extra for those supported by the medication compared to those supported by placebo.

"In this study, dapagliflozin seemed to better glucose power including under the need for insulin, while skilfully while origin some mass loss," said Dr. Sue Kirkman, higher ranking failing chief of state of medical affairs including society details of the American Diabetes Association.

"This is an interesting study supported by a modern medication that's below development. It has a novel mechanism of action, however there own been some in progress concerns regarding the safety of this class of medications, including none has been received through the FDA yet," she noted.

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SOURCES: John Wilding, D.M., professor, medicine, unofficial consulting specialist including head, department of fatness including endocrinology, Institute of Aging including Chronic Disease, Clinical Sciences Centre, University Hospital Aintree, Liverpool, England; Sue Kirkman, M.D., higher ranking failing president, medical affairs including society information, American Diabetes Association; March 20, 2012, Annals of Internal Medicine